Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
ZEMICEF 200 MG is indicated for the treatment of the following infections caused by susceptible microorganisms:
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Upper Respiratory Tract Infections (URTI):
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Otitis media
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Pharyngitis and tonsillitis caused by Streptococcus pyogenes
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Lower Respiratory Tract Infections:
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Acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae
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Urinary Tract Infections:
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Cystitis, cystourethritis, pyelonephritis caused by Escherichia coli and Proteus mirabilis
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Sexually Transmitted Diseases:
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Uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae
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Other Infections:
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Typhoid fever caused by Salmonella typhi
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Pharmacology:
Cefixime is a third-generation semisynthetic cephalosporin antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death. It exhibits bactericidal activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Cefixime is highly stable in the presence of beta-lactamase enzymes, making it effective against organisms resistant to penicillins and some cephalosporins. Absorption is approximately 40% to 50%, irrespective of food intake.
Dosage & Administration:
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Adults and Children over 12 years:
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200–400 mg daily, administered as a single dose or in two divided doses.
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For uncomplicated gonorrhea: 400 mg as a single dose.
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For typhoid fever: 20 mg/kg body weight daily in two divided doses. The usual treatment duration is 7 days, extendable up to 14 days based on infection severity.
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Children (6 months and older):
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8 mg/kg/day, administered as a single dose or in two divided doses.
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Specific dosing based on age:
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6 months to 1 year: 75 mg daily
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1 to 4 years: 100 mg daily
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5 to 10 years: 200 mg daily
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11 to 12 years: 300 mg daily
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For typhoid fever: 15–20 mg/kg/day, divided into two doses, for 7–14 days.
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Administration:
Take ZEMICEF 200 MG orally with or without food. Swallow the capsule whole with a glass of water. Do not crush or chew the capsule.
Interaction:
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Carbamazepine: Concurrent use may increase plasma concentrations of carbamazepine.
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Warfarin and other anticoagulants: Concurrent use may prolong prothrombin time. Monitoring is recommended.
Contraindications:
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Hypersensitivity to Cefixime or other cephalosporin antibiotics.
Side Effects:
Common side effects include:
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Gastrointestinal disturbances:
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Diarrhea
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Nausea
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Abdominal pain
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Dyspepsia
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Vomiting
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Flatulence
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Central nervous system effects:
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Headache
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Dizziness
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Hypersensitivity reactions:
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Rash
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Pruritus
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Urticaria
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Drug fever
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Arthralgia
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These reactions are generally mild and resolve upon discontinuation of therapy.
Pregnancy & Lactation:
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Pregnancy: Use during pregnancy should be considered only if the potential benefit justifies the potential risk to the fetus.
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Lactation: Cefixime is excreted in breast milk. Caution should be exercised when administering to nursing mothers.
Therapeutic Class:
Third-generation cephalosporin antibiotic.
Storage Conditions:
Store below 30°C in a cool, dry place, away from light. Keep out of reach of children.
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