• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Carvista is indicated for:
Mild to moderate chronic heart failure (in combination with ACE inhibitors, diuretics, and digitalis)
Hypertension (high blood pressure)
Left ventricular dysfunction following myocardial infarction to improve survival
Pharmacology:
Carvedilol is a non-selective beta-adrenergic blocker and alpha-1 blocker. It reduces cardiac output and peripheral vascular resistance by blocking beta-1, beta-2, and alpha-1 receptors. This dual action decreases heart rate and dilates blood vessels, thereby reducing blood pressure and myocardial workload.
Dosage & Administration:
Heart failure: Start with 3.125 mg twice daily for 2 weeks. If tolerated, dose may be doubled every 2 weeks to a maximum of 25 mg twice daily.
Hypertension: Initial dose is 6.25 mg twice daily; may be increased to 25 mg twice daily if needed.
Should be taken with food to slow absorption and reduce risk of orthostatic hypotension.
Interaction:
May enhance the effect of other antihypertensives and digoxin
Risk of bradycardia or AV block with calcium channel blockers (e.g., verapamil, diltiazem)
May mask hypoglycemia symptoms in diabetics
Use with caution when combined with CYP2D6 inhibitors (e.g., fluoxetine)
Contraindications:
Bronchial asthma or related bronchospastic conditions
Second- or third-degree AV block
Severe bradycardia or cardiogenic shock
Decompensated heart failure requiring IV inotropes
Severe liver impairment
Side Effects:
Common: Dizziness, fatigue, hypotension, bradycardia, weight gain, diarrhea
Less common: Hyperglycemia, visual disturbances, dyspnea, depression
Pregnancy & Lactation:
Use only if clearly needed during pregnancy; may affect fetal circulation. Caution is advised in lactating women as it's unknown whether Carvedilol passes into breast milk.
Precautions & Warnings:
Monitor blood pressure, heart rate, blood glucose, and renal function during therapy
Do not stop abruptly; taper gradually to avoid rebound effects
Use with caution in patients with diabetes, COPD, or liver dysfunction
Therapeutic Class:
Non-selective beta-blockers with alpha-blocking activity
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.