Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
🔸 Indications:
Lopirel Plus is indicated for:
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Prevention of atherothrombotic events in patients with recent myocardial infarction (MI), stroke, or established peripheral arterial disease
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Secondary prevention of cardiovascular events
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Management of hypertension with cardiac risk
🔸 Pharmacology:
Lopirel Plus is a combination of Clopidogrel (an antiplatelet agent) and Aspirin (acetylsalicylic acid, an NSAID with antiplatelet effects).
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Clopidogrel inhibits ADP-induced platelet aggregation by irreversibly binding to P2Y12 receptors.
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Aspirin irreversibly inhibits COX-1, reducing thromboxane A2 formation, further preventing platelet aggregation.
Together, they reduce the risk of thrombotic cardiovascular events.
🔸 Dosage:
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Usual adult dose: Clopidogrel 75 mg + Aspirin 75 mg once daily
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Or as directed by the physician based on individual cardiac risk profile
🔸 Administration:
Take orally with water, preferably after food to minimize gastric irritation. Do not crush or chew.
🔸 Interaction:
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Increased bleeding risk with anticoagulants (e.g., warfarin, heparin)
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NSAIDs and SSRIs may enhance gastrointestinal bleeding risk
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Omeprazole may reduce clopidogrel's effectiveness
Inform your doctor about all medicines including over-the-counter drugs and supplements.
🔸 Contraindications:
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Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage)
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Severe liver dysfunction
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Hypersensitivity to clopidogrel, aspirin, or NSAIDs
🔸 Side Effects:
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Bleeding (nosebleeds, bruising, GI bleeding)
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Dyspepsia
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Nausea
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Rash
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Rare: Thrombocytopenia, agranulocytosis
Seek immediate help if signs of serious bleeding or allergic reaction appear.
🔸 Pregnancy & Lactation:
Use only if clearly needed and prescribed by a physician.
Aspirin may cause complications in the third trimester.
🔸 Precautions & Warnings:
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Monitor for signs of bleeding, especially in elderly patients
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Use cautiously in patients with history of peptic ulcer or bleeding disorders
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Liver function and platelet count monitoring may be required during prolonged use
🔸 Therapeutic Class:
Antiplatelet Agent (Clopidogrel + Aspirin combination)
Cardiovascular Risk Reducer
🔸 Storage Conditions:
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Store below 25°C
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Protect from moisture and light
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Keep out of reach of children
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