MODESTO XR 6MG is a sustained-release tablet containing 6 milligrams of guanfacine. Guanfacine is an alpha-2A adrenergic receptor agonist used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children, adolescents, and adults. 1 The extended-release formulation is designed for once-daily administration, providing a steady release of the medication to help improve focus, reduce impulsivity, and decrease hyperactivity throughout the day. It works by affecting specific receptors in the brain, leading to improved attention and behavioral regulation.