Description
Sardopa 250 mg Tablet contains Methyldopa, a centrally acting antihypertensive medication. It is primarily used to manage hypertension (high blood pressure), including cases associated with pregnancy. Methyldopa functions by being converted into its active form, α-methylnorepinephrine, in the central nervous system. This active metabolite stimulates α-2 adrenergic receptors in the brainstem, leading to a reduction in sympathetic nervous system activity, thereby lowering blood pressure. The exact mechanism is not fully elucidated, but it is believed to involve inhibition of norepinephrine release and reduction in sympathetic tone. Sardopa is typically administered in divided doses, with the initial dosage adjusted based on the patient's response. The maximum recommended daily dosage is 3 grams. Common side effects may include sedation, headache, and weakness, while more serious effects can involve liver dysfunction, hematologic abnormalities, and central nervous system symptoms. Methyldopa is contraindicated in patients with active hepatic disease or those receiving monoamine oxidase inhibitors. Caution is advised in patients with a history of liver disease, depression, or Parkinsonism. It is classified as a pregnancy category B drug and appears in breast milk; therefore, its use during pregnancy and lactation should be under medical supervision.
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