Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
NOBESIT XR 500 is indicated as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus, especially in overweight individuals.
Pharmacology:
Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. The extended-release formulation allows slow release for prolonged effect.
Dosage & Administration:
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Adults: Starting dose is usually 500 mg once daily with the evening meal.
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Dose may be gradually increased based on blood glucose response, up to a maximum of 2000 mg per day.
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Take with food to reduce gastrointestinal side effects. Do not crush or chew the tablet.
Interaction:
Caution with alcohol, iodinated contrast agents, and other antidiabetic drugs. May interact with beta-blockers, diuretics, corticosteroids, and ACE inhibitors.
Contraindications:
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Renal impairment (eGFR <30 mL/min/1.73 m²)
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Metabolic acidosis, including diabetic ketoacidosis
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Severe hepatic impairment
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Hypersensitivity to Metformin
Side Effects:
Common: Nausea, vomiting, diarrhea, abdominal pain, loss of appetite.
Rare but serious: Lactic acidosis (life-threatening).
Pregnancy & Lactation:
Generally considered safe during pregnancy if necessary. Should be used during lactation only if prescribed by a physician.
Precautions & Warnings:
Regular monitoring of renal function is essential. Use with caution in elderly and patients undergoing radiologic studies involving contrast agents. Avoid excessive alcohol intake.
Therapeutic Class:
Biguanide oral antidiabetics
Storage Conditions:
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
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