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Description
TACROLIM 0.1% Ointment is a topical immunosuppressant medication manufactured by Incepta Pharmaceuticals Ltd., containing 0.1% tacrolimus as its active ingredient. It is primarily indicated for the treatment of moderate to severe atopic dermatitis (eczema) in patients who have not responded adequately to conventional therapies or when such therapies are inadvisable due to potential risks. Additionally, TACROLIM is used to manage various other skin conditions, including chronic cutaneous graft-versus-host disease, hand and foot eczema, allergic contact dermatitis, vitiligo, psoriasis, lichen planus, facial lichen, vulvar lichen sclerosus, pyoderma gangrenosum, leg ulcers in rheumatoid arthritis, steroid-induced rosacea, alopecia areata, annular erythema, chronic actinic dermatitis, and recalcitrant facial erythema .
Tacrolimus, the active component, is a macrolide immunomodulator produced by the fungus Streptomyces tsukubaensis. It functions by inhibiting T-lymphocyte activation through binding to an intracellular protein, FKBP-12. This complex formation interferes with the phosphatase activity of calcineurin, leading to a decrease in the entire inflammatory cascade
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