Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
ARNIS 50 MG is indicated for:
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Management of chronic heart failure with reduced ejection fraction (HFrEF).
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Reducing the risk of cardiovascular mortality and heart failure-related hospitalization.
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Improving the efficiency and function of the heart in affected patients.
Pharmacology
ARNIS is a combination of Sacubitril, a neprilysin inhibitor, and Valsartan, an angiotensin receptor blocker (ARB). This dual-action medication reduces vascular resistance and sodium retention, thereby improving heart function and reducing strain on the cardiovascular system.
Dosage and Administration
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Standard dose: One tablet (50 mg) twice daily or as directed by a healthcare provider.
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Administer orally, with or without food.
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Dosage adjustments may be required based on patient tolerance, kidney function, or other clinical factors.
Interaction
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Should not be used alongside ACE inhibitors to avoid angioedema risk.
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May interact with potassium supplements, NSAIDs, and other antihypertensives.
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Caution advised when combined with lithium or aliskiren.
Contraindications
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Hypersensitivity to Sacubitril, Valsartan, or any tablet components.
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History of angioedema linked to ACE inhibitors or ARBs.
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Significant liver impairment or advanced renal disease.
Side Effects
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Common: Low blood pressure (hypotension), dizziness, or fatigue.
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Rare: Angioedema, hyperkalemia, or worsening kidney function.
Pregnancy & Lactation
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Contraindicated during pregnancy due to risk to the developing fetus.
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Not recommended during breastfeeding as its safety profile is not well established.
Precautions & Warnings
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Blood pressure, kidney function, and serum potassium levels should be regularly monitored.
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Avoid abrupt discontinuation to prevent clinical deterioration.
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Use cautiously in individuals with electrolyte imbalances or a history of angioedema.
Therapeutic Class
Antihypertensive and heart failure therapy.
Storage Conditions
Store at a temperature below 30°C, in a cool and dry place, away from direct sunlight and moisture. Keep out of reach of children.
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