Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
📄 Long Description
Indications:
ROXIM M 50ML is indicated for the treatment of infections caused by susceptible microorganisms, including:
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Respiratory infections: pneumonia, acute and chronic bronchitis, bronchopneumonia
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ENT infections: tonsillitis, pharyngitis, sinusitis, otitis media
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Skin infections: folliculitis, furuncles, cellulitis, carbuncles, pyoderma, impetigo, infected dermatitis
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Genital infections: urethritis, prostatitis, cervicitis, salpingitis, especially caused by Chlamydia trachomatis
Pharmacology:
Roxithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing transpeptidation and translocation reactions. It is effective against Gram-positive bacteria like Staphylococcus and Streptococcus, as well as Gram-negative bacteria such as Haemophilus influenzae and atypical pathogens like Mycoplasma and Chlamydia.
Dosage:
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Adults: 300 mg once daily or 150 mg twice daily for 5–10 days.
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Children: 2.5 to 5 mg/kg body weight twice daily.
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6–11 kg: 25 mg every 12 hours
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12–23 kg: 50 mg every 12 hours
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24–40 kg: 100 mg every 12 hours
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Administration:
Administer orally on an empty stomach, preferably 15 minutes before meals. Shake the suspension well before use.
Interaction:
Roxithromycin has minimal interaction with cytochrome P-450 enzymes, reducing the likelihood of drug interactions. Mild interactions may occur with theophylline, but these are not clinically significant. No notable interactions with carbamazepine or warfarin have been observed.
Contraindications:
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Hypersensitivity to Roxithromycin or other macrolide antibiotics
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Concurrent use with ergotamine or its derivatives, due to the risk of arterial spasm and severe ischemia
Side Effects:
Common side effects include nausea, abdominal pain, diarrhea, and skin rash. Less frequently, patients may experience vomiting, dizziness, headache, pruritus, dyspepsia, flatulence, tinnitus, vertigo, and constipation. These side effects are generally mild and transient.
Pregnancy & Lactation:
The safety of Roxithromycin during pregnancy has not been established. It is excreted in small amounts in breast milk but is not known to cause adverse effects in nursing infants. Use during pregnancy and lactation should be based on a physician's recommendation.
Precautions & Warnings:
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Use with caution in patients with hepatic impairment; dosage adjustment may be necessary.
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Monitor liver function during prolonged therapy.
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Avoid use in patients with a history of arrhythmias.
Therapeutic Class:
Macrolide Antibiotics
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
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