• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Menopausal symptoms such as hot flashes, night sweats, and vaginal dryness
Prevention and treatment of postmenopausal osteoporosis
Pharmacology:
Tibolone is a synthetic steroid with estrogenic, progestogenic, and androgenic properties. It is metabolized into three active metabolites: 3α-hydroxytibolone and 3β-hydroxytibolone (estrogenic effects), and the Δ4-isomer (progestogenic and androgenic effects). These metabolites act on various tissues to alleviate menopausal symptoms and prevent bone loss.
Dosage & Administration:
Adults: 2.5 mg orally once daily
Administration: Swallow the tablet whole with water, at the same time each day
Starting Treatment: Initiate at least 12 months after the last natural menstrual period or immediately in women with surgical menopause
Switching from HRT: Begin tibolone the day after completing a sequential HRT regimen or at any time after a continuous-combined HRT regimen
Interaction:
May interact with enzyme-inducing drugs like barbiturates, carbamazepine, and rifampicin, potentially reducing tibolone's effectiveness
May enhance the effects of anticoagulants due to increased fibrinolytic activity
Contraindications:
Hypersensitivity to tibolone or any component of the tablet
History of breast cancer or endometrial cancer
Undiagnosed vaginal bleeding
Severe liver disease
History of thromboembolic disorders
Side Effects:
Common: Weight gain, abdominal pain, breast tenderness, headache, mood changes
Less common: Acne, increased hair growth, vaginal bleeding
Serious: Risk of stroke, breast cancer, endometrial cancer
Pregnancy & Lactation:
Pregnancy: Contraindicated; may harm the developing fetus
Lactation: Not recommended; may affect milk production and composition
Precautions & Warnings:
Regular monitoring is advised, including breast exams and mammography
Not recommended for women with a history of hormone-sensitive cancers
Use with caution in women with cardiovascular risk factors
Therapeutic Class:
Hormone Replacement Therapy (HRT)
Storage Conditions:
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.