Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
📄 Long Description
Indications:
Sitazid M 50/500 is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both Sitagliptin and Metformin is appropriate.
Pharmacology:
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Sitagliptin: A DPP-4 inhibitor that increases the levels of incretin hormones, enhancing insulin secretion and decreasing glucagon levels in a glucose-dependent manner.
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Metformin: A biguanide that decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.
Dosage:
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Adults: One tablet (Sitagliptin 50mg + Metformin 500mg) taken orally twice daily with meals. Dosage should be individualized based on the patient's current regimen, effectiveness, and tolerability.
Administration:
Take Sitazid M 50/500 with meals to reduce gastrointestinal side effects. Swallow the tablet whole; do not crush or chew.
Interaction:
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Alcohol: Increases the risk of lactic acidosis.
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Cationic drugs (e.g., amiloride, digoxin): May compete for common renal tubular transport systems, increasing metformin levels.
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Insulin or insulin secretagogues: May increase the risk of hypoglycemia when used concomitantly.
Contraindications:
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Renal impairment (e.g., serum creatinine ≥1.5 mg/dL in males or ≥1.4 mg/dL in females)
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis
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Hypersensitivity to Sitagliptin, Metformin, or any component of the formulation
Side Effects:
Common side effects include:
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Diarrhea
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Nausea
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Vomiting
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Headache
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Upper respiratory tract infection
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Hypoglycemia (especially when combined with insulin or sulfonylureas)
Pregnancy & Lactation:
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Pregnancy: Use only if clearly needed and if the potential benefit justifies the potential risk to the fetus.
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Lactation: It is unknown whether Sitagliptin or Metformin is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Precautions & Warnings:
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Monitor renal function before initiating therapy and periodically thereafter.
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Use with caution in patients with hepatic impairment.
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Discontinue in cases of dehydration, severe infection, or hypoxemia.
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Temporarily discontinue before any radiologic studies involving intravascular administration of iodinated contrast materials.
Therapeutic Class:
Combination oral hypoglycemic preparations
Storage Conditions:
Store at a temperature below 30°C. Protect from light and moisture. Keep out of reach of children.
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