Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
SK-Cef DS is indicated for the treatment of infections caused by susceptible organisms, including:
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Upper respiratory tract infections: pharyngitis, sinusitis, otitis media, tonsillitis, laryngo-tracheo-bronchitis.
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Lower respiratory tract infections: acute and chronic bronchitis, lobar and bronchopneumonia.
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Urinary tract infections: cystitis, urethritis, pyelonephritis.
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Skin and soft tissue infections: abscess, cellulitis, furunculosis, impetigo.
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Osteomyelitis and septic arthritis.
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Bacterial sepsis and peritonitis.
Pharmacology:
Cephradine is a semisynthetic broad-spectrum bactericidal antibiotic belonging to the first-generation cephalosporins. It is active against both gram-positive and gram-negative microorganisms. Cephradine inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis.
Dosage:
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Adults:
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Urinary tract infections: 500 mg four times daily or 1 g twice daily.
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Respiratory tract infections: 250–500 mg four times daily or 500 mg–1 g twice daily.
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Skin and soft tissue infections: 250–500 mg four times daily or 500 mg–1 g twice daily.
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Maximum daily dosage: 4 g.
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Children:
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General infections: 25–50 mg/kg/day in divided doses every 6–12 hours.
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Otitis media: 75–100 mg/kg/day in divided doses every 6–12 hours.
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Administration:
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For oral suspension: Reconstitute the powder by adding 70 ml of boiled and cooled water in two portions, shaking well after each addition. Shake the suspension well before each use.
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Can be taken with or without food; however, food may delay absorption slightly.
Interaction:
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Concurrent use with nephrotoxic drugs (e.g., aminoglycosides) may increase the risk of kidney damage.
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Probenecid may decrease renal clearance of Cephradine, leading to higher serum concentrations.
Contraindications:
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Patients with known hypersensitivity to cephalosporin antibiotics.
Side Effects:
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Gastrointestinal disturbances: nausea, vomiting, diarrhea, abdominal pain.
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Hypersensitivity reactions: skin rashes, urticaria, pruritus.
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Rarely: eosinophilia, leukopenia, neutropenia, positive Coombs test, pseudomembranous colitis.
Pregnancy & Lactation:
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Use during pregnancy only if clearly needed and prescribed by a physician.
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Cephradine is excreted in breast milk; caution is advised when administered to nursing mothers.
Precautions & Warnings:
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Use with caution in patients with a history of hypersensitivity to penicillins, due to potential cross-reactivity.
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Adjust dosage in patients with impaired renal function.
Therapeutic Class:
First-generation Cephalosporins.
Storage Conditions:
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Store the dry powder at room temperature, protected from light and moisture.
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After reconstitution, store the suspension in a refrigerator (2°C–8°C) and use within 7 days.
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