Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications
GTN 400 MCG Spray is indicated for:
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Angina Pectoris: Rapid relief and prevention of chest pain associated with angina.
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Heart Attack Risk Reduction: As part of a broader treatment plan under medical supervision.
Pharmacology
Glyceryl trinitrate, a nitrate compound, works by converting to nitric oxide in the body, which relaxes vascular smooth muscles. This leads to:
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Dilation of coronary arteries, enhancing blood flow to the heart.
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Reduction in myocardial oxygen demand by decreasing preload and afterload.
Dosage and Administration
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Dosage:
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For acute angina: 1 or 2 sprays under the tongue at the onset of pain. Repeat after 5 minutes if necessary, up to a maximum of 3 doses within 15 minutes.
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Prophylactic use: 1 or 2 sprays 5–10 minutes before exertion or exposure to trigger factors.
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Administration:
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Shake the container. Spray directly under the tongue while seated to avoid dizziness. Do not inhale.
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Interaction
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Potentiates Hypotensive Effects: With alcohol, antihypertensives, or PDE5 inhibitors (e.g., sildenafil).
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Reduced Effectiveness: With long-term nitrate use due to tolerance.
Contraindications
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Hypersensitivity to nitrates.
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Severe hypotension or hypovolemia.
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Concurrent use with PDE5 inhibitors (e.g., sildenafil).
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Severe anemia or intracranial hypertension.
Side Effects
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Common: Headache, dizziness, flushing, and hypotension.
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Rare: Methemoglobinemia or severe hypotensive episodes.
Pregnancy & Lactation
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Pregnancy: Use only if clearly necessary and prescribed by a healthcare provider.
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Lactation: Safety not established; consult a physician before use.
Precautions & Warnings
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Avoid abrupt discontinuation to prevent rebound angina.
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Use cautiously in patients with low blood pressure or hypovolemia.
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Sit or lie down while using to prevent dizziness or fainting.
Therapeutic Class
Nitrate (Anti-anginal).
Storage Conditions
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Store below 25°C in a cool, dry place.
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Protect from direct sunlight and heat sources.
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Keep out of reach of children.
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