• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
Prophylactic treatment of bronchial asthma
Symptomatic treatment of allergic conditions including rhinitis and conjunctivitis
Alleviating the complications of itching, pain, and tenderness associated with neurofibroma
Symptomatic treatment of allergy such as hay fever, urticaria
Pharmacology:
Ketotifen is a potent anti-allergic substance possessing a powerful and sustained non-competitive histamine (H1) receptor blocking property. It inhibits the release of mediators (e.g., histamine, leukotrienes, and prostaglandins) from cells responsible for type-I allergic reactions. Ketotifen also stabilizes mast cells, decreases chemotaxis, and activation of degranulation of eosinophils, making it effective in preventing asthmatic attacks.
Dosage & Administration:
Adults: 1 mg twice daily with food. If necessary, the dose may be increased to 2 mg twice daily in severe cases.
Children above 3 years: 1 mg twice daily with food. Patients known to be easily sedated should begin treatment with 0.5 to 1 mg at night for the first few days or as directed by the physician.
Use in elderly: Same as adult dose or as advised by the physician.
Interaction:
Toti may potentiate the effects of sedatives, hypnotics, antihistamines, and alcohol.
A reversible fall in the platelet count has been observed in a few patients receiving Toti concomitantly with oral antidiabetic agents, and it has been suggested that this combination should therefore be avoided.
Contraindications:
Hypersensitivity to ketotifen or any of the components of the tablet.
Not for use in acute asthma attacks.
Not recommended for children under 3 years of age.
Side Effects:
Common: Drowsiness, dry mouth, slight dizziness.
Less Common: Weight gain, rash, respiratory infection, abdominal pain, increased appetite, epistaxis, puffy eyelid, sleep disturbance.
Pregnancy & Lactation:
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus.
Lactation: It is not known whether ketotifen is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Precautions & Warnings:
Prolonged use may lead to systemic absorption and potential side effects.
Use with caution in patients with impaired peripheral circulation or diabetes.
Avoid application on broken skin, mucous membranes, or the anogenital region.
Not for prolonged use in high concentrations and on large areas of the body.
Therapeutic Class:
Cromoglycate & related drugs
Storage Conditions:
Store in a cool and dry place, protected from light. Keep out of reach of children