Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
SK-Cef 500 mg Capsule is indicated for the treatment of infections caused by susceptible organisms, including:
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Upper respiratory tract infections: pharyngitis, sinusitis, otitis media, tonsillitis.
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Lower respiratory tract infections: bronchitis, pneumonia.
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Urinary tract infections: cystitis, pyelonephritis.
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Skin and soft tissue infections: cellulitis, impetigo.
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Osteomyelitis and septic arthritis.
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Bacterial sepsis and peritonitis.
Pharmacology:
Cephradine is a semisynthetic broad-spectrum bactericidal antibiotic belonging to the first-generation cephalosporins. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis.
Dosage:
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Adults:
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Urinary tract infections: 500 mg every 12 hours.
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Respiratory tract infections: 250–500 mg every 6 hours or 500 mg every 12 hours.
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Skin and soft tissue infections: 250–500 mg every 6 hours or 500 mg every 12 hours.
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Maximum daily dose: 4 g.
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Children:
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General infections: 25–50 mg/kg/day in divided doses every 6–12 hours.
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Otitis media: 75–100 mg/kg/day in divided doses every 6–12 hours.
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Administration:
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Take with or without food.
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Swallow the capsule whole with a glass of water.
Interaction:
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Concurrent use with nephrotoxic drugs (e.g., aminoglycosides) may increase the risk of kidney damage.
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Probenecid may decrease renal clearance of Cephradine, leading to higher serum concentrations.
Contraindications:
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Patients with known hypersensitivity to cephalosporin antibiotics.
Side Effects:
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Gastrointestinal disturbances: nausea, vomiting, diarrhea, abdominal pain.
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Hypersensitivity reactions: skin rashes, urticaria, pruritus.
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Rarely: eosinophilia, leukopenia, neutropenia, positive Coombs test, pseudomembranous colitis.
Pregnancy & Lactation:
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Use during pregnancy only if clearly needed and prescribed by a physician.
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Cephradine is excreted in breast milk; caution is advised when administered to nursing mothers.
Precautions & Warnings:
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Use with caution in patients with a history of hypersensitivity to penicillins, due to potential cross-reactivity.
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Adjust dosage in patients with impaired renal function.
Therapeutic Class:
First-generation Cephalosporins.
Storage Conditions:
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Store at room temperature, away from light and moisture.
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Keep out of reach of children.
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