Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications
GLUNOR 850MG Tablet is indicated for:
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Type 2 Diabetes Mellitus: To improve blood sugar control in adults and children above 10 years of age when diet and exercise alone are insufficient.
Pharmacology
Metformin is a biguanide that works by:
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Decreasing hepatic glucose production.
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Increasing peripheral glucose uptake and utilization.
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Improving insulin sensitivity.
It does not stimulate insulin secretion, reducing the risk of hypoglycemia.
Dosage and Administration
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Dosage:
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Adults: Start with 500mg or 850mg once daily, gradually increasing to a maximum of 2550mg daily in divided doses.
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Children (10 years and above): Start with 500mg once daily, up to a maximum of 2000mg daily.
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Administration:
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Take with or after meals to reduce gastrointestinal side effects.
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Interaction
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Increased Risk of Lactic Acidosis: With alcohol or iodinated contrast agents.
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Reduced Efficacy: With corticosteroids, diuretics, or beta-agonists.
Contraindications
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Hypersensitivity to Metformin.
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Severe renal impairment (eGFR < 30 mL/min/1.73 m²).
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
Side Effects
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Common: Gastrointestinal disturbances like nausea, diarrhea, and abdominal discomfort.
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Rare: Lactic acidosis, vitamin B12 deficiency.
Pregnancy & Lactation
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Pregnancy: Metformin may be used if prescribed; consult a healthcare provider.
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Lactation: Excreted in breast milk but generally considered safe with monitoring.
Precautions & Warnings
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Monitor renal function regularly.
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Avoid alcohol consumption to reduce the risk of lactic acidosis.
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Discontinue temporarily before surgery or radiological studies involving contrast agents.
Therapeutic Class
Biguanide (Antidiabetic).
Storage Conditions
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Store below 30°C in a cool, dry place.
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Protect from light and moisture.
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Keep out of reach of children.
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