Description
• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications:
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Type 2 Diabetes Mellitus (T2DM) in adults
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When treatment with Empagliflozin or Metformin alone does not provide adequate glycemic control
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To reduce cardiovascular risks in diabetic patients with established cardiovascular disease
Pharmacology:
This fixed-dose combination contains:
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Empagliflozin: A selective SGLT2 inhibitor that promotes urinary glucose excretion by inhibiting reabsorption of glucose in the kidneys.
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Metformin: A biguanide that decreases hepatic glucose production and improves insulin sensitivity, thereby lowering blood glucose levels.
Dosage:
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The usual starting dose is 5 mg Empagliflozin / 500 mg Metformin twice daily
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Dose may be titrated based on patient’s glycemic control
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Maximum dose: 25 mg Empagliflozin / 2000 mg Metformin per day
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Adjust dose cautiously in patients with renal impairment
Administration:
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Take orally twice daily with meals to reduce gastrointestinal side effects
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Swallow tablets whole with water
Interaction:
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Alcohol increases the risk of lactic acidosis with Metformin
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Diuretics and other antihypertensives may enhance the risk of dehydration and hypotension
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Avoid co-administration with cationic drugs (e.g., cimetidine) that compete for renal tubular transport with Metformin
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Risk of hypoglycemia when used with insulin or insulin secretagogues
Contraindications:
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Severe renal impairment or end-stage renal disease
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis
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Hypersensitivity to either component
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Type 1 diabetes
Side Effects:
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Common: Nausea, diarrhea, urinary tract infections, genital mycotic infections
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Rare: Lactic acidosis (Metformin), ketoacidosis (Empagliflozin), dehydration
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Flatulence, abdominal discomfort, and dizziness
Pregnancy & Lactation:
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Should be avoided during pregnancy unless clearly necessary
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Not recommended during breastfeeding
Precautions & Warnings:
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Monitor renal function before and during treatment
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Avoid excessive alcohol consumption
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Stop treatment in cases of dehydration, surgery, or serious infections
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Educate patient about signs of lactic acidosis and ketoacidosis
Therapeutic Class:
Combination Oral Hypoglycemic Agents (SGLT2 Inhibitor + Biguanide)
Storage Conditions:
Store below 30°C, in a dry place away from direct sunlight and moisture. Keep out of reach of children.
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