LINAROL M 850 MG

LINAROL M 850 MG

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Product Code : 106519638100402

Short Description

Linarol-M 850 mg is a combination of Linagliptin and Metformin Hydrochloride, used to improve glycemic control in adults with type 2 diabetes mellitus when both medications are appropriate.

Name	Brand	Generic Name	Strength	PPF	Price
LINAROL M 850 MG	Drug International Ltd.	LINAGLIPTIN+ METFORMIN HCL	850 mg	TABLET	14

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

Indications:
Linarol-M 850 mg is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both Linagliptin and Metformin is appropriate.

Pharmacology:

Linagliptin: A DPP-4 inhibitor that increases and prolongs the activity of incretin hormones, leading to enhanced insulin release and reduced glucagon secretion in a glucose-dependent manner.
Metformin Hydrochloride: A biguanide that decreases hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Dosage:

Initial Dose: In patients not currently treated with Metformin, initiate with 2.5 mg Linagliptin and 500 mg Metformin twice daily with meals.
Maintenance Dose: The dosage should be individualized based on effectiveness and tolerability, not exceeding 2.5 mg Linagliptin and 1000 mg Metformin twice daily with meals.

Administration:
Take the tablet orally with meals to reduce gastrointestinal side effects associated with Metformin.

Interaction:

Cationic Drugs: May reduce Metformin elimination.
P-glycoprotein/CYP3A4 Inducers: Rifampin may decrease Linagliptin exposure, reducing its efficacy.
Other Drugs Affecting Glycemic Control: Certain drugs may produce hyperglycemia, leading to loss of glycemic control.

Contraindications:

Hypersensitivity to Linagliptin or Metformin Hydrochloride.
Renal impairment (eGFR <30 mL/min/1.73 m²).
Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
Hepatic insufficiency.

Side Effects:

Common: Nasopharyngitis, diarrhea.
Less Common: Hypoglycemia (especially when used with sulfonylureas), nausea, vomiting, abdominal discomfort.

Pregnancy & Lactation:

Pregnancy: Category B. Should be used during pregnancy only if clearly needed.
Lactation: Caution should be exercised when administered to a nursing woman.

Therapeutic Class:
Combination Oral Hypoglycemic Preparations

Storage Conditions:
Store in a cool, dry place below 25°C and away from direct sunlight. Keep all medicines out of reach of children.