MYGEST 200 MG

MYGEST 200 MG

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Product Code : 106510143200101

Short Description

MYGEST 200 is a natural micronized progesterone used for hormone replacement therapy, menstrual disorders, and support in pregnancy-related hormonal imbalance.

Name	Brand	Generic Name	Strength	PPF	Price
MYGEST 200 MG	Drug International Ltd.	PROGESTERONE ( MICRONIZED )	200 mg	Capsule	30

৳ 30

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

Indications:

গর্ভাবস্থার রক্ষণাবেক্ষণ, বিশেষ করে Threatened বা Recurrent abortion ক্ষেত্রে।
IUI ও ART প্রক্রিয়ায় luteal support।
luteal phase insufficiency।
মেনোপজ পরবর্তী হরমোন রিপ্লেসমেন্ট থেরাপি (HRT)।
Endometrial hyperplasia প্রতিরোধ।
Secondary amenorrhoea-তে progesterone challenge test।
Dysfunctional uterine bleeding (DUB)।
Premenstrual syndrome (PMS)।
Endometriosis।
Oocyte donation প্রোগ্রাম।
Benign mastopathy।

Pharmacology:

Mygest 200 mg Capsule contains micronized progesterone, which is structurally and biologically identical to natural endogenous progesterone. Micronization increases the bioavailability of progesterone. When micronized progesterone is administered after meals, maximal serum progesterone levels are significantly increased. Progesterone concentrations in the endometrial and breast tissue attain high levels. Progesterone is approximately 96%-99% bound to serum proteins, primarily to serum albumin (50%-54%). Progesterone is metabolized to pregnanediols and pregnanolones in the liver. The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the bile and urine. Progesterone metabolites, which are excreted in bile, may undergo enterohepatic circulation.

Dosage & Administration:

Maintenance of Pregnancy: 200–400 mg/day in divided doses.
In-vitro Fertilization (IVF) & Embryo Transfer: 200 mg thrice daily until pregnancy confirmation; continue until the 12th week if pregnant.
Hormone Replacement Therapy (HRT):
- Sequential regimen: 200 mg daily for 12 days in the last 2 weeks of each therapeutic cycle.
- Continuous regimen: 100 mg daily throughout the month along with estrogen.
Luteal Support: 100 mg thrice daily from the 17th day of the cycle for 10 days; continue until the 12th week of pregnancy if pregnant.
Luteal Phase Insufficiency: 100 mg thrice daily, increasing by 100 mg/week to a maximum of 600 mg/day if required.
Secondary Amenorrhoea: 300 mg daily for 10 days.
Premenstrual Syndrome: 100–200 mg daily for 10 days from the 17th to 26th day of each menstrual cycle.
Benign Mastopathy: 200–300 mg for 10 days per month, usually from the 17th to 26th day of the monthly cycle.

Administration:

Oral Use: Take with food to enhance absorption and reduce gastrointestinal discomfort.

Interaction:

Ketoconazole inhibits the metabolism of progesterone.

Contraindications:

Hypersensitivity to progesterone or any excipients in the formulation.
Liver dysfunction.
Undiagnosed vaginal bleeding.
Porphyria.
Cancers of the uterus and genital organs.
Breast cancers.
History of stroke or blood clots.
Should not be used in a case of miscarriage with tissue left in the uterus.

Side Effects:

Common: Abdominal pain, nausea, abnormal vaginal bleeding, edema, hair loss, abdominal bloating, headache, breast pain, vomiting, vaginal yeast infection.
Less common: Dizziness, drowsiness, mood changes, diarrhea, joint pain, constipation.

Pregnancy & Lactation:

Pregnancy: Safe if prescribed; most studies have shown low or no risk to the developing baby.
Breastfeeding: Safe if prescribed; human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Therapeutic Class: