LOSARDIL PLUS 25/12.5

LOSARDIL PLUS 25/12.5

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Product Code : 106519639500501

Short Description

Losardil 25/12.5 mg is a combination of Losartan Potassium and Hydrochlorothiazide used to treat hypertension and reduce the risk of stroke in hypertensive patients with left ventricular hypertrophy.

Name	Brand	Generic Name	Strength	PPF	Price
LOSARDIL PLUS 25/12.5	Drug International Ltd.	LOSARTAN POTASSIUM	Plus 25/12.5	TABLET	5.05

৳ 5.05

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Description

• রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

Indications:
Losardil 25/12.5 mg is indicated for the treatment of hypertension and to reduce the risk of stroke in hypertensive patients with left ventricular hypertrophy. It may be used alone or in combination with other antihypertensive agents.

Pharmacology:

Losartan Potassium: An angiotensin II receptor antagonist that selectively blocks the binding of angiotensin II to the AT₁ receptor, leading to vasodilation and reduced secretion of aldosterone.
Hydrochlorothiazide: A thiazide diuretic that inhibits sodium and chloride reabsorption in the distal convoluted tubule, leading to increased excretion of sodium, chloride, and water.

Dosage:

Hypertension: The usual starting dose is 50 mg of Losartan and 12.5 mg of Hydrochlorothiazide once daily. The dose may be increased to 100 mg/25 mg once daily if necessary.
Stroke Risk Reduction in LVH: The recommended dose is 50 mg of Losartan and 12.5 mg of Hydrochlorothiazide once daily. If additional blood pressure reduction is needed, the dose may be increased to 100 mg/25 mg once daily.

Administration:
Take the tablet orally with or without food, swallowed whole with a glass of water.

Interaction:

Potassium Supplements: Concurrent use with potassium supplements or potassium-sparing diuretics may lead to hyperkalemia.
NSAIDs: Nonsteroidal anti-inflammatory drugs may reduce the antihypertensive effect of Losartan.
Other Antihypertensive Agents: Concurrent use may have an additive effect.

Contraindications:

Hypersensitivity to Losartan Potassium or any of the excipients.
Pregnancy (especially during the second and third trimesters).
Severe hepatic or renal impairment.

Side Effects:
Common side effects include dizziness, headache, fatigue, and upper respiratory tract infections. Less common side effects may include hypotension, hyperkalemia, and gastrointestinal disturbances.

Pregnancy & Lactation:

Pregnancy: Contraindicated during pregnancy, especially during the second and third trimesters.
Lactation: Caution should be exercised when administered to a nursing woman.

Therapeutic Class:
Angiotensin II Receptor Blocker + Thiazide Diuretic Combination

Storage Conditions:
Store in a cool, dry place below 25°C, away from direct sunlight. Keep out of reach of children.