Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
DANILO 60MG Tablet is indicated for:
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Treatment of mild to moderate hypertension.
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Management of chronic stable angina and variant angina (Prinzmetal's angina).
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Controlling heart rate in supraventricular tachycardia and atrial fibrillation/flutter.
Pharmacology
Diltiazem, a non-dihydropyridine calcium channel blocker, inhibits calcium ion influx in cardiac and vascular smooth muscle. This action decreases myocardial oxygen demand, increases oxygen delivery, and reduces systemic vascular resistance, which is beneficial in hypertension and angina.
Dosage & Administration
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Hypertension: 30-60 mg twice daily, titrated based on clinical response.
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Angina: 30-90 mg three to four times daily, adjusted as needed.
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Administration: Take orally with water, with or without food. Do not crush or chew the tablet.
Interaction
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Drug Interactions:
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Enhanced effects when used with beta-blockers, digoxin, or antihypertensive agents.
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Interactions with CYP3A4 inhibitors or inducers can alter drug levels.
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Food Interactions: Avoid grapefruit juice as it may increase drug concentration.
Contraindications
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Severe hypotension (systolic BP <90 mmHg).
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Second- or third-degree AV block without a pacemaker.
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Recent myocardial infarction with pulmonary congestion.
Side Effects
Common side effects:
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Dizziness, headache, and nausea.
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Fatigue, flushing.
Rare or severe side effects:
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Bradycardia, hypotension.
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Peripheral edema, skin rash.
Pregnancy & Lactation
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Pregnancy: Use only when clearly needed; may pose risks to the fetus (Category C).
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Lactation: Diltiazem is excreted in breast milk; consult a healthcare provider before use.
Precautions & Warnings
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Monitor heart rate and blood pressure regularly.
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Use cautiously in patients with hepatic or renal impairment.
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Avoid abrupt discontinuation to prevent rebound angina or hypertension.
Therapeutic Class
Calcium channel blocker (non-dihydropyridine).
Storage Conditions
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Store at room temperature below 30°C.
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Protect from direct sunlight and moisture.
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Keep out of the reach of children.
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