Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
SERGEL 40 MG Capsule is indicated for:
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Management of Gastroesophageal Reflux Disease (GERD).
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Healing and prevention of peptic ulcers, especially those caused by H. pylori or NSAID use.
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Zollinger-Ellison syndrome, characterized by excessive stomach acid production.
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Erosive esophagitis.
Pharmacology:
Esomeprazole, the active ingredient, is a proton pump inhibitor (PPI) that inhibits the hydrogen-potassium ATPase enzyme in gastric parietal cells. This action significantly reduces stomach acid production, alleviating symptoms and promoting mucosal healing.
Dosage and Administration:
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Adults: 40 mg once daily, preferably at least 1 hour before meals.
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The duration of treatment varies based on the condition, usually 4-8 weeks for GERD.
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Swallow the capsule whole; do not crush or chew.
Interaction:
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May reduce the absorption of medications like ketoconazole or atazanavir that require an acidic gastric pH.
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Use with caution in patients taking anticoagulants like warfarin due to an increased risk of bleeding.
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Concomitant use with clopidogrel may reduce its effectiveness.
Contraindications:
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Hypersensitivity to esomeprazole, other proton pump inhibitors, or any excipients in the formulation.
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Severe liver impairment without appropriate dose adjustments.
Side Effects:
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Common: Headache, nausea, abdominal discomfort, diarrhea, and flatulence.
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Rare but serious: Hypomagnesemia, vitamin B12 deficiency, and increased risk of fractures with prolonged use.
Pregnancy & Lactation:
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Pregnancy: Esomeprazole is classified as FDA Category B; safe when prescribed by a healthcare provider.
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Lactation: Caution is advised as esomeprazole may pass into breast milk.
Precautions & Warnings:
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Long-term use may lead to increased risks of gastrointestinal infections like Clostridium difficile.
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Monitor magnesium and vitamin B12 levels during extended treatment.
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Discontinue use immediately if severe hypersensitivity reactions occur.
Therapeutic Class:
Proton Pump Inhibitor (PPI)
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from moisture and direct sunlight. Keep out of reach of children.
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