Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
GLYMIN XR 500 MG is indicated for:
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Type 2 diabetes mellitus (non-insulin dependent), especially in overweight adults
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Can be used as monotherapy or in combination with other antidiabetic agents
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Helps improve glycemic control without causing weight gain or hypoglycemia
Pharmacology:
GLYMIN XR contains Metformin Hydrochloride (Extended Release), a biguanide hypoglycemic agent that works by:
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Reducing hepatic glucose production
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Delaying intestinal glucose absorption
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Enhancing insulin sensitivity and peripheral glucose uptake
The XR (extended-release) formulation provides gradual release over time, reducing gastrointestinal side effects and offering better compliance.
Dosage & Administration:
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Usual starting dose: 500 mg once daily with the evening meal
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Dose may be increased in 500 mg increments weekly based on blood glucose monitoring
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Maximum dose: 2000 mg/day
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Swallow whole with water; do not crush or chew
Interaction:
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Alcohol may increase risk of lactic acidosis
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Iodinated contrast agents (in radiology) may interact; discontinue temporarily
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Drugs like cimetidine and furosemide may increase plasma metformin concentration
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May enhance effect of other antidiabetics (risk of hypoglycemia)
Contraindications:
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Renal impairment (eGFR < 30 mL/min/1.73 m²)
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Acute metabolic acidosis (e.g., ketoacidosis, lactic acidosis)
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Hepatic dysfunction
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Cardiovascular collapse, heart failure, or shock
Side Effects:
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Common: Bloating, flatulence, mild nausea, diarrhea (less than with IR formulation)
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Rare: Lactic acidosis (life-threatening), taste disturbance, B12 deficiency
Pregnancy & Lactation:
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Category B: Can be used in pregnancy under medical supervision
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Excreted in breast milk in small amounts; use only if clearly needed
Precautions & Warnings:
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Regularly monitor renal and hepatic function
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Temporarily discontinue in case of surgery, severe infection, or dehydration
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Avoid excessive alcohol consumption
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Use cautiously in elderly patients
Therapeutic Class:
Biguanide – Extended Release Oral Hypoglycemic Agent
Storage Conditions:
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of children’s reach.
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