Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
VORIFAST 100 MG TABLET is indicated for the treatment of invasive fungal infections, including invasive aspergillosis, systemic candidiasis, and infections caused by other rare fungi.
Pharmacology:
Voriconazole is a triazole antifungal that inhibits the fungal cytochrome P450 enzyme, leading to a reduction in ergosterol synthesis. This disrupts the fungal cell membrane, effectively stopping fungal growth.
Dosage & Administration:
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Adults: 200 mg twice daily (loading dose for the first 24 hours: 400 mg twice daily). Adjust dose as required by the physician.
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Children (2-12 years): Dosage is weight-based and must be determined by a healthcare provider.
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Administer at least one hour before or after meals.
Interaction:
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Avoid concurrent use with drugs like rifampin, carbamazepine, or barbiturates as they can reduce Voriconazole effectiveness.
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Voriconazole may increase the plasma levels of certain medications, including warfarin and phenytoin.
Contraindications:
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Hypersensitivity to Voriconazole or any of its components.
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Concomitant use with drugs that are contraindicated due to potential for severe interactions.
Side Effects:
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Common: Visual disturbances, rash, headache, and nausea.
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Serious: Hepatotoxicity, QT prolongation, or hypersensitivity reactions.
Pregnancy & Lactation:
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Not recommended during pregnancy unless clearly necessary due to potential risks to the fetus.
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Use caution in lactating mothers as the drug may pass into breast milk.
Precautions & Warnings:
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Monitor liver function tests regularly during treatment.
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Use cautiously in patients with pre-existing liver or kidney conditions.
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Avoid direct sunlight exposure as photosensitivity reactions may occur.
Therapeutic Class:
Systemic antifungal agents.
Storage Conditions:
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
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