Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
GLYMIN 500 MG is indicated for:
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Management of type 2 diabetes mellitus
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Used alone or in combination with other antidiabetic medications
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Especially beneficial in overweight diabetic patients
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Helps reduce the risk of diabetes-related complications
Pharmacology:
GLYMIN contains Metformin Hydrochloride, a biguanide class oral hypoglycemic agent. It works primarily by:
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Decreasing hepatic glucose production
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Reducing intestinal glucose absorption
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Improving insulin sensitivity and peripheral glucose uptake
Unlike sulfonylureas, metformin does not stimulate insulin secretion, thereby reducing the risk of hypoglycemia.
Dosage & Administration:
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Initial dose: 500 mg once or twice daily with meals
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Maximum daily dose: Up to 2000–2500 mg (in divided doses)
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Must be taken with food to minimize gastrointestinal side effects
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Dose adjustments should be based on blood glucose monitoring and physician guidance
Interaction:
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Alcohol may increase the risk of lactic acidosis
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Cimetidine, furosemide, and nifedipine may affect metformin levels
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May interact with contrast agents used in imaging; temporarily discontinue before procedures
Contraindications:
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Renal impairment (eGFR < 30 mL/min/1.73 m²)
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Acute or chronic metabolic acidosis, including diabetic ketoacidosis
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Severe hepatic dysfunction
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Conditions that predispose to hypoxia (e.g., heart failure, respiratory failure)
Side Effects:
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Common: Nausea, diarrhea, abdominal pain, metallic taste
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Rare but serious: Lactic acidosis (life-threatening)
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Long-term use may reduce vitamin B12 absorption
Pregnancy & Lactation:
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Category B: Generally considered safe during pregnancy under physician supervision
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Use with caution during lactation
Precautions & Warnings:
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Monitor renal function regularly
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Avoid excessive alcohol intake
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Stop temporarily before radiologic studies with contrast dye
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Not recommended in type 1 diabetes or for diabetic ketoacidosis
Therapeutic Class:
Biguanide-type oral hypoglycemic agent
Storage Conditions:
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
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