Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
EVAGLIP 25 MG/5 MG is indicated for:
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Type 2 diabetes mellitus in adults who are not adequately controlled on monotherapy with vildagliptin or metformin.
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As an adjunct to diet and exercise to improve glycemic control.
Pharmacology:
This medication combines:
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Vildagliptin 50 mg daily dose equivalent (5 mg twice daily) – a DPP-4 inhibitor that enhances incretin hormone activity, stimulating insulin release and reducing glucagon secretion.
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Metformin 25 mg – a biguanide that reduces hepatic glucose production and improves peripheral insulin sensitivity. (Note: Low-dose formulation for patients requiring mild metformin exposure)
Dosage & Administration:
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Recommended dose: One tablet twice daily with meals.
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Adjustments may be made by the physician based on individual response and renal function.
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Always administer with food to minimize GI side effects.
Interaction:
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Use caution with other antidiabetic drugs (e.g., sulfonylureas, insulin) – may increase hypoglycemia risk.
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Alcohol may increase risk of lactic acidosis with metformin.
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Possible interaction with diuretics, corticosteroids, and beta-blockers.
Contraindications:
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Hypersensitivity to vildagliptin, metformin, or formulation components
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Renal impairment (eGFR <30 mL/min)
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Metabolic acidosis or lactic acidosis
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Hepatic dysfunction or liver enzyme elevations
Side Effects:
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Common: Diarrhea, nausea, flatulence, headache
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Less common: Abdominal discomfort, dizziness
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Rare: Lactic acidosis, pancreatitis, hepatic dysfunction, rash
Pregnancy & Lactation:
Not recommended unless clearly necessary. Metformin may pass into breast milk; vildagliptin's effects on breastfeeding are unknown. Use with caution.
Precautions & Warnings:
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Regularly monitor renal and hepatic function
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Discontinue temporarily in conditions such as dehydration, severe infection, or surgery
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Monitor for symptoms of lactic acidosis (e.g., muscle pain, breathing difficulty)
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Avoid alcohol
Therapeutic Class:
Oral antidiabetic combination – DPP-4 inhibitor + Biguanide
Storage Conditions:
Store below 30°C, protected from light and moisture. Keep out of reach of children.
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