Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
SERGEL 40 MG IV Injection is indicated for:
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Management of Gastroesophageal Reflux Disease (GERD) when oral therapy is not feasible.
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Treatment of peptic ulcers and erosive esophagitis.
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Zollinger-Ellison syndrome in critical care settings.
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Prevention of stress-induced ulcers in hospitalized patients.
Pharmacology:
Esomeprazole is a proton pump inhibitor (PPI) that blocks the H+/K+ ATPase enzyme system in gastric parietal cells. This action effectively suppresses stomach acid secretion, providing relief from symptoms and facilitating healing in acid-related conditions. The IV form ensures rapid and effective acid suppression in hospitalized or critically ill patients.
Dosage and Administration:
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Adults: 40 mg once daily, administered intravenously over 3 minutes or as an infusion over 10-30 minutes.
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For severe cases, repeat dosing may be required as advised by a healthcare provider.
Preparation and Administration:
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Reconstitute the vial with the provided solvent or as per manufacturer guidelines.
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Administer immediately after preparation to avoid degradation.
Interaction:
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May reduce the efficacy of drugs requiring acidic pH for absorption (e.g., ketoconazole, atazanavir).
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Use with caution in patients on anticoagulants like warfarin due to an increased risk of bleeding.
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May reduce the effectiveness of clopidogrel when used concurrently.
Contraindications:
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Hypersensitivity to esomeprazole, other PPIs, or any excipient in the formulation.
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Severe hepatic impairment without dose adjustment.
Side Effects:
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Common: Headache, injection site reactions, nausea, diarrhea.
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Rare: Hypomagnesemia, bone fractures with long-term use, and severe allergic reactions.
Pregnancy & Lactation:
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Pregnancy: Esomeprazole is categorized as FDA Category B; safe when prescribed by a healthcare professional.
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Lactation: Use with caution; esomeprazole may pass into breast milk.
Precautions & Warnings:
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Avoid prolonged use without periodic assessment to prevent potential adverse effects like vitamin B12 deficiency.
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Monitor magnesium levels during prolonged therapy.
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Discontinue use and consult a physician if severe hypersensitivity reactions occur.
Therapeutic Class:
Proton Pump Inhibitor (PPI)
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from light and moisture. Reconstituted solutions should be used immediately.
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