Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
PALZEN 0.5 MG is indicated for the prevention of:
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Acute and delayed nausea and vomiting associated with highly or moderately emetogenic chemotherapy
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Postoperative nausea and vomiting (PONV)
Pharmacology:
Palonosetron is a selective 5-HT3 receptor antagonist that prevents nausea and vomiting by blocking serotonin (5-HT) receptors in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract. It has a long half-life (~40 hours), offering prolonged antiemetic protection compared to other drugs in its class.
Dosage & Administration:
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For chemotherapy-induced nausea:
0.5 mg orally about 1 hour before chemotherapy -
For postoperative nausea:
0.5 mg orally approximately 1 hour prior to anesthesia -
Use as directed by a registered physician
Interaction:
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Caution when combined with other serotonergic drugs (risk of serotonin syndrome)
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No significant interaction with CYP450 enzyme inhibitors or inducers
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Does not require dose adjustment with corticosteroids
Contraindications:
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Hypersensitivity to Palonosetron or other 5-HT3 antagonists
Side Effects:
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Common: Headache, constipation, dizziness
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Less common: Fatigue, abdominal pain
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Rare: Hypersensitivity reactions, serotonin syndrome (if used with other serotonergic agents)
Pregnancy & Lactation:
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Pregnancy: Use only if clearly needed (Category B)
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Lactation: Unknown if excreted in breast milk; caution advised
Precautions & Warnings:
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Caution in patients with prolonged QT interval
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Monitor for signs of serotonin syndrome when used with serotonergic drugs
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Not for chronic use; use only before chemotherapy or surgery
Therapeutic Class:
5-HT3 receptor antagonists (Antiemetics)
Storage Conditions:
Store below 30°C. Keep in a dry place away from light and moisture. Keep out of reach of children.
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