Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
ORICEF 1 GM is indicated for the treatment of:
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Lower respiratory tract infections
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Urinary tract infections (UTIs)
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Skin and soft tissue infections
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Intra-abdominal infections
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Bone and joint infections
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Bacterial septicemia
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Meningitis
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Gonorrhea
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Surgical prophylaxis
Pharmacology:
Ceftriaxone is a third-generation cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). It is highly stable against most beta-lactamases and effective against a wide range of Gram-positive and Gram-negative organisms.
Dosage & Administration:
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Adults: 1–2 g once daily or in two divided doses
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Severe infections: Up to 4 g/day
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Children: 50–75 mg/kg/day
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Administer via intravenous (IV) or intramuscular (IM) injection
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Reconstitute with appropriate diluent before use
Interaction:
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May increase nephrotoxicity when used with aminoglycosides
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May increase bleeding risk with anticoagulants
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Calcium-containing IV solutions must not be co-administered in neonates
Contraindications:
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Hypersensitivity to cephalosporins
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Known allergy to penicillins (cross-reactivity risk)
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Hyperbilirubinemic neonates (risk of kernicterus)
Side Effects:
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Common: Diarrhea, rash, pain at injection site
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Less common: Eosinophilia, elevated liver enzymes
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Rare: Anaphylaxis, pseudomembranous colitis, hemolytic anemia
Pregnancy & Lactation:
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Pregnancy Category B: Generally considered safe
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Excreted in breast milk; use with caution in lactating mothers
Precautions & Warnings:
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Monitor renal and hepatic function during prolonged therapy
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Discontinue if signs of hypersensitivity occur
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Caution in patients with history of gastrointestinal disease, especially colitis
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Ensure adequate hydration during high-dose therapy
Therapeutic Class:
Third-generation cephalosporins
Storage Conditions:
Store below 25°C. Protect from light and moisture. After reconstitution, use within the recommended timeframe. Keep out of reach of children.
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