Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
OPAL 20 MG is indicated for the treatment of:
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Gastroesophageal Reflux Disease (GERD)
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Duodenal and Gastric Ulcers
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Zollinger-Ellison Syndrome
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Erosive Esophagitis
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H. pylori eradication (as part of combination therapy)
Pharmacology:
Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells. It reduces both basal and stimulated acid production, promoting ulcer healing and symptom relief.
Dosage & Administration:
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Usual adult dose: 20 mg once daily before a meal
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Duration: 4–8 weeks depending on condition
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In H. pylori eradication: Used with antibiotics (e.g., amoxicillin and clarithromycin)
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Dose adjustment needed in hepatic impairment
Interaction:
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May decrease absorption of drugs like ketoconazole, atazanavir
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May increase blood levels of warfarin, phenytoin, diazepam
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Caution with clopidogrel as it may reduce antiplatelet effect
Contraindications:
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Known hypersensitivity to Omeprazole or other PPIs
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Severe liver disease (use cautiously)
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Concomitant use with nelfinavir
Side Effects:
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Common: Headache, abdominal pain, nausea, constipation, flatulence
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Less common: Dizziness, rash, dry mouth
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Long-term use: Risk of vitamin B12 deficiency, hypomagnesemia, bone fracture
Pregnancy & Lactation:
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Generally considered safe in pregnancy (Category C)
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Excreted in breast milk; use with caution during lactation
Precautions & Warnings:
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Rule out gastric malignancy before starting therapy
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Long-term use may cause nutrient absorption issues
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Caution in patients with osteoporosis
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May mask symptoms of serious gastrointestinal diseases
Therapeutic Class:
Proton Pump Inhibitors (PPIs)
Storage Conditions:
Store below 30°C in a dry place, away from direct sunlight. Keep out of reach of children.
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