Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
VORIFAST 40ML SUSPENSION is indicated for the treatment of severe and life-threatening fungal infections, including invasive aspergillosis, systemic candidiasis, and other rare fungal infections.
Pharmacology:
Voriconazole is a broad-spectrum antifungal agent that inhibits fungal cytochrome P450-dependent enzymes, reducing ergosterol synthesis. This action compromises the integrity of the fungal cell membrane, inhibiting fungal growth.
Dosage & Administration:
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Adults:
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Loading Dose: 6 mg/kg every 12 hours for the first 24 hours.
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Maintenance Dose: 4 mg/kg every 12 hours, adjusted based on response.
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Children (2-12 years): Weight-based dosing as advised by the physician.
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Shake well before use. Administer at least one hour before or after meals.
Interaction:
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Avoid co-administration with drugs like rifampin, carbamazepine, or long-acting barbiturates due to reduced effectiveness of Voriconazole.
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Voriconazole may interact with medications like warfarin, cyclosporine, and phenytoin, requiring monitoring and dose adjustments.
Contraindications:
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Hypersensitivity to Voriconazole or any components of the suspension.
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Concurrent use with contraindicated drugs due to potential for severe interactions.
Side Effects:
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Common: Visual disturbances, rash, nausea, and headache.
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Serious: Hepatotoxicity, QT prolongation, and hypersensitivity reactions.
Pregnancy & Lactation:
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Not recommended during pregnancy unless necessary due to potential risks to the fetus.
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Use with caution during lactation, as the medication may be present in breast milk.
Precautions & Warnings:
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Regular monitoring of liver and kidney function during therapy is recommended.
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Avoid prolonged sunlight exposure due to photosensitivity risks.
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Use cautiously in patients with pre-existing cardiac arrhythmias or electrolyte imbalances.
Therapeutic Class:
Systemic antifungal agents.
Storage Conditions:
Store below 30°C in a cool, dry place. Protect from direct sunlight and moisture. Keep out of reach of children. Shake well before each use.
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