রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
EVAGLIP 10 MG/5 MG is indicated for:
Treatment of type 2 diabetes mellitus in adults who are not adequately controlled on metformin or vildagliptin alone.
As an adjunct to diet and exercise to improve glycemic control.
Pharmacology:
EVAGLIP is a fixed-dose combination of Vildagliptin (50 mg) and Metformin (500/1000 mg).
Vildagliptin is a DPP-4 inhibitor that enhances the levels of active incretin hormones, improving insulin secretion and reducing glucagon levels.
Metformin decreases hepatic glucose production and improves insulin sensitivity in peripheral tissues.
Dosage & Administration:
Typically, one tablet twice daily with meals or as directed by a physician.
Dose adjustments may be required based on patient’s renal function and previous therapy.
Administer with food to reduce gastrointestinal side effects.
Interaction:
Caution with other hypoglycemic agents or insulin (may cause hypoglycemia).
Alcohol may potentiate the effect of metformin (lactic acidosis risk).
Use caution with diuretics, corticosteroids, and beta-blockers.
Contraindications:
Hypersensitivity to vildagliptin, metformin, or any excipients
Renal impairment (eGFR < 30 mL/min)
Acute or chronic metabolic acidosis (e.g., lactic acidosis)
Hepatic dysfunction
Side Effects:
Common: Nausea, diarrhea, headache, dizziness
Less common: Flatulence, upper respiratory tract infection
Rare: Lactic acidosis (from metformin), pancreatitis (from vildagliptin), elevated liver enzymes
Pregnancy & Lactation:
Not recommended during pregnancy unless clearly necessary. Metformin is excreted in breast milk; vildagliptin’s safety in lactation is unknown. Use with caution.
Precautions & Warnings:
Monitor renal and liver function regularly
Discontinue in case of conditions predisposing to hypoxia or dehydration
Watch for signs of lactic acidosis and pancreatitis
Avoid alcohol consumption
Therapeutic Class:
Oral Anti-diabetic drugs – DPP-4 inhibitor + Biguanide combination
Storage Conditions:
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.