REPLET 75 MG

REPLET 75 MG

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Product Code : 109319615801801

Short Description

An antiplatelet medication used to prevent heart attacks and strokes by inhibiting platelet aggregation

Name	Brand	Generic Name	Strength	PPF	Price
REPLET 75 MG	Healthcare Pharmaceuticals Ltd.	CLOPIDOGREL	75 mg	TABLET	12

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Description

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

Indications:

Replet 75 mg Tablet is indicated for:

Acute Coronary Syndrome (ACS): Reduces the rate of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS (unstable angina/NSTEMI).
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: Reduces the rate of MI and stroke in patients with established peripheral arterial disease or with a history of recent MI or stroke.

Pharmacology:

Clopidogrel is a prodrug that inhibits platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses. Repeated doses of 75 mg per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches steady state between Day 3 and Day 7.

Dosage and Administration:

Acute Coronary Syndrome: Initiate with a single 300 mg (4 tablets) oral loading dose, then continue at 75 mg once daily.
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: 75 mg once daily orally without a loading dose.
Can be taken with or without food.

Interaction:

Increased risk of bleeding when used with NSAIDs, warfarin, SSRIs, or SNRIs.
Avoid concomitant use with omeprazole or esomeprazole as they inhibit CYP2C19, affecting Clopidogrel metabolism.
Avoid concomitant use with repaglinide due to increased plasma concentrations of repaglinide.

Contraindications:

Hypersensitivity to Clopidogrel or any component of the product.
Active pathological bleeding such as peptic ulcer or intracranial hemorrhage.

Side Effects:

Common: Bleeding, diarrhea, gastrointestinal discomfort, skin reactions.
Rare: Acquired hemophilia, anemia, angioedema, arthralgia, arthritis, bone marrow disorders.

Pregnancy & Lactation:

There are no adequate and well-controlled studies in pregnant women. Replet 75 mg should be used during pregnancy only if clearly needed. It is unknown whether Clopidogrel is excreted in human breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Precautions & Warnings:

Clopidogrel is a prodrug; metabolism to its active metabolite is impaired by genetic variations in CYP2C19 and by drugs that inhibit CYP2C19 such as omeprazole and esomeprazole.
As it inhibits platelet aggregation for the lifetime of the platelet (7-10 days), the risk of bleeding may increase.
Discontinue 5 days prior to elective surgery that has a major risk of bleeding.
Thrombotic Thrombocytopenic Purpura (TTP) has been reported and requires urgent treatment including plasmapheresis.