Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*
Indications:
NITRIN SR 6.4 MG is indicated for:
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Prevention of angina pectoris associated with coronary artery disease
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Management of chronic stable angina
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Sometimes used as adjunctive therapy in heart failure (off-label)
Pharmacology:
Glyceryl Trinitrate (GTN) is a nitrate that works by relaxing vascular smooth muscle, leading to vasodilation. It reduces myocardial oxygen demand by decreasing preload and afterload, and improves oxygen delivery to the heart, reducing chest pain.
Dosage & Administration:
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Usual adult dose: 6.4 mg once or twice daily, adjusted as per response
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Administer with water, preferably at the same time daily
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Ensure a nitrate-free interval (typically at night) to avoid tolerance
Interaction:
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Serious hypotension can occur with phosphodiesterase inhibitors (e.g., sildenafil, tadalafil)
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Potentiates the effect of antihypertensives and alcohol
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Use cautiously with diuretics, calcium channel blockers, and beta-blockers
Contraindications:
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Known hypersensitivity to nitrates
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Severe anemia
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Hypotension or circulatory collapse
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Concomitant use with PDE-5 inhibitors
Side Effects:
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Common: Headache, dizziness, lightheadedness, flushing
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Less common: Nausea, tachycardia, hypotension
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Rare: Methemoglobinemia, skin rash
Pregnancy & Lactation:
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Use during pregnancy only if clearly necessary and prescribed
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Safety during lactation is not well-established; use with caution
Precautions & Warnings:
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Do not use continuously without medical supervision to avoid tolerance
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Avoid sudden posture changes to prevent orthostatic hypotension
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Monitor blood pressure regularly in long-term use
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Use with caution in patients with glaucoma or increased intracranial pressure
Therapeutic Class:
Nitrates – Anti-anginal Preparations
Storage Conditions:
Store below 25°C in a dry place away from direct sunlight. Keep out of reach of children.
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