Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
SERGEL MUPS 40 MG Tablet is indicated for:
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Treatment of severe Gastroesophageal Reflux Disease (GERD).
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Healing of peptic ulcers caused by H. pylori or NSAID use.
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Zollinger-Ellison syndrome.
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Erosive esophagitis.
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Long-term maintenance therapy for acid-related disorders.
Pharmacology:
Esomeprazole in MUPS form ensures controlled release and optimal absorption. As a proton pump inhibitor (PPI), it inhibits the H+/K+ ATPase enzyme system in gastric parietal cells, reducing gastric acid secretion and facilitating mucosal healing.
Dosage and Administration:
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Adults: 40 mg once daily, preferably taken 1 hour before meals.
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The treatment duration is usually 4-8 weeks, depending on the condition.
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Swallow the tablet whole; do not crush, chew, or split.
Interaction:
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May reduce the absorption of drugs like ketoconazole and atazanavir requiring acidic gastric pH.
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Use cautiously with anticoagulants such as warfarin due to increased bleeding risks.
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May reduce the effectiveness of clopidogrel when administered concurrently.
Contraindications:
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Hypersensitivity to esomeprazole, other PPIs, or any components of the formulation.
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Severe liver impairment without proper dose adjustments.
Side Effects:
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Common: Headache, abdominal discomfort, nausea, diarrhea, and flatulence.
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Rare: Hypomagnesemia, vitamin B12 deficiency, and bone fractures with long-term use.
Pregnancy & Lactation:
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Pregnancy: Safe under medical supervision (FDA Category B).
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Lactation: Use with caution, as esomeprazole may pass into breast milk.
Precautions & Warnings:
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Prolonged use may increase the risk of gastrointestinal infections or bone fractures.
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Regular monitoring of magnesium and vitamin B12 levels is recommended during extended therapy.
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Discontinue immediately if severe allergic reactions occur.
Therapeutic Class:
Proton Pump Inhibitor (PPI)
Storage Conditions:
Store below 30°C in a dry place, away from moisture and direct sunlight. Keep out of reach of children.
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