Description
রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।
Indications:
SERGEL MUPS 20 MG Tablet is indicated for:
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Gastroesophageal Reflux Disease (GERD).
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Peptic ulcers caused by H. pylori infection or NSAID use.
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Zollinger-Ellison syndrome.
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Erosive esophagitis.
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Maintenance therapy for acid-related disorders.
Pharmacology:
Esomeprazole in MUPS form ensures uniform and controlled release in the stomach. It works as a proton pump inhibitor (PPI), inhibiting the H+/K+ ATPase enzyme in gastric parietal cells, effectively reducing stomach acid production and promoting healing.
Dosage and Administration:
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Adults: 20 mg once daily, preferably 1 hour before meals.
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The duration of treatment depends on the condition, typically 4-8 weeks for GERD.
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Swallow the tablet whole with water; do not crush or chew.
Interaction:
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May reduce absorption of drugs like ketoconazole and atazanavir requiring an acidic environment.
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Use with caution alongside warfarin due to an increased risk of bleeding.
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Reduces the efficacy of clopidogrel when used concurrently.
Contraindications:
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Hypersensitivity to esomeprazole, other proton pump inhibitors, or any ingredient in the formulation.
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Severe liver impairment without appropriate dose adjustments.
Side Effects:
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Common: Nausea, headache, diarrhea, flatulence, and abdominal discomfort.
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Rare but serious: Hypomagnesemia, vitamin B12 deficiency, and increased fracture risk with prolonged use.
Pregnancy & Lactation:
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Pregnancy: Considered safe under medical supervision (FDA Category B).
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Lactation: Use with caution as esomeprazole may pass into breast milk.
Precautions & Warnings:
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Prolonged use may lead to vitamin B12 deficiency or increase risks of bone fractures.
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Monitor magnesium levels during extended treatment.
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Discontinue use if severe allergic reactions occur.
Therapeutic Class:
Proton Pump Inhibitor (PPI)
Storage Conditions:
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.
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