DINOVO 500/20MG

DINOVO 500/20MG

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Product Code : 103119647000302

Short Description

DINOVO 500/20MG is a combination of Naproxen and Esomeprazole for pain relief and prevention of NSAID-induced gastric ulcers.

Name	Brand	Generic Name	Strength	PPF	Price
DINOVO 500/20MG	Beximco Pharmaceuticals Ltd.	NAPROXEN+ESOMEPRAZOLE	500/20mg	TABLET	15

৳ 15

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Description

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন*

Indications:
DINOVO 500/20MG is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and for reducing the risk of NSAID-associated gastric ulcers in patients requiring long-term NSAID therapy.

Pharmacology:

Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis through cyclooxygenase (COX) inhibition, reducing inflammation and pain.
Esomeprazole is a proton pump inhibitor (PPI) that reduces gastric acid secretion by blocking the H+/K+ ATPase in gastric parietal cells, thereby minimizing the risk of ulceration caused by prolonged NSAID use.

Dosage:

One tablet once or twice daily as prescribed by the physician.
Should be used at the lowest effective dose for the shortest duration necessary.

Administration:
Take orally at least 30 minutes before meals. Swallow the tablet whole; do not chew or crush.

Interaction:

Naproxen may interact with anticoagulants, diuretics, ACE inhibitors, and other NSAIDs.
Esomeprazole may interact with clopidogrel, digoxin, ketoconazole, and diazepam.
Avoid concurrent use with other ulcerogenic drugs unless advised by a physician.

Contraindications:

Hypersensitivity to Naproxen, Esomeprazole, or similar drugs.
History of gastrointestinal bleeding or perforation.
Severe hepatic or renal insufficiency.
Active peptic ulcer disease.

Side Effects:
May include abdominal pain, nausea, heartburn, headache, dizziness, constipation, or flatulence. Rare but serious effects: GI bleeding, kidney or liver dysfunction, allergic reactions.

Pregnancy & Lactation:
Not recommended during the third trimester of pregnancy. Should be used during pregnancy or lactation only if clearly necessary and under medical supervision.

Precautions & Warnings:

Caution in patients with a history of ulcers, cardiovascular disease, or kidney/liver disorders.
Avoid alcohol and smoking.
Monitor for gastrointestinal symptoms during prolonged use.

Therapeutic Class:
NSAID with gastroprotective agent (Fixed-dose combination)

Storage Conditions:
Store below 30°C in a cool, dry place away from sunlight. Keep out of reach of children.