রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Indications
LOSPAN 10 mg is indicated for:
Treatment of hypertension (high blood pressure)
Reducing the risk of stroke in patients with high blood pressure and left ventricular hypertrophy
Kidney protection in type 2 diabetic patients with proteinuria
Management of heart failure in patients intolerant to ACE inhibitors
Pharmacology
LOSPAN contains Losartan Potassium, an angiotensin II receptor blocker (ARB). It blocks the binding of angiotensin II to AT1 receptors, preventing vasoconstriction and aldosterone secretion. This results in vasodilation, reduced blood pressure, and decreased workload on the heart and kidneys.
Dosage & Administration
Usual adult dose: 25–100 mg daily in single or divided doses
Initial dose: 10 mg may be considered for elderly or those with liver impairment
Dosage should be adjusted based on response
Can be taken with or without food
Interaction
May enhance the effects of other antihypertensive drugs
Increased risk of hyperkalemia with potassium supplements or potassium-sparing diuretics
NSAIDs may reduce antihypertensive effect
May interact with lithium and increase its toxicity
Contraindications
Hypersensitivity to Losartan or any component of the product
Pregnancy (especially in 2nd and 3rd trimester)
Severe hepatic impairment
Side Effects
Common: Dizziness, fatigue, nasal congestion, back pain
Less common: Hyperkalemia, hypotension, kidney dysfunction, dry cough (less than ACE inhibitors)
Pregnancy & Lactation
Pregnancy: Contraindicated. Can cause injury or death to the developing fetus.
Lactation: Not recommended. Safety in breastfeeding is not established.
Precautions & Warnings
Monitor blood pressure, renal function, and serum potassium regularly
Use with caution in patients with liver or kidney impairment
Avoid in pregnancy and ensure effective contraception during use
May cause dizziness; caution while driving
Therapeutic Class
Angiotensin II Receptor Blockers (ARBs)
Antihypertensive agent
Storage Conditions
Store below 30°C in a dry place away from light and moisture. Keep out of reach of children.